John D Hulleman Selected Research

Doyne honeycomb retinal dystrophy

12/2023	GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.
1/2023	Ocular Amyloid, Condensates, and Aggregates - Higher-Order Protein Assemblies Participate in Both Retinal Degeneration and Function.
1/2021	Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization.
1/2016	Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-Related Macular Degeneration and Potential Therapies.
1/2015	Differential tolerance of 'pseudo-pathogenic' tryptophan residues in calcium-binding EGF domains of short fibulin proteins.
11/2012	Translational attenuation differentially alters the fate of disease-associated fibulin proteins.
12/2011	Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration.

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John D Hulleman Research Topics

Disease

9	Macular Degeneration (Age-Related Maculopathy) 05/2024 - 12/2011
8	Retinal Degeneration 01/2024 - 02/2015
7	Doyne honeycomb retinal dystrophy 12/2023 - 12/2011
5	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 05/2007
5	Parkinson Disease (Parkinson's Disease) 01/2020 - 05/2007
3	Glaucoma 05/2024 - 01/2022
3	Retinal Diseases 01/2024 - 01/2017
3	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/2022 - 04/2016
3	Neoplasms (Cancer) 01/2018 - 09/2014
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2023 - 01/2021
2	Eye Diseases (Eye Disease) 05/2022 - 08/2019
1	Retinal Dystrophies 12/2023
1	Escherichia coli Infections 01/2021
1	Vision Disorders (Hemeralopia) 01/2021
1	Atrophy 01/2021
1	Adenocarcinoma of Lung 01/2020
1	Synucleinopathies 01/2020
1	Fuchs' Endothelial Dystrophy 01/2020
1	Neoplasm Metastasis (Metastasis) 01/2020
1	Infections 12/2019
1	Osteogenesis Imperfecta (Lobstein Disease) 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2018
1	Inflammation (Inflammations) 01/2017
1	Amyloidosis 11/2014
1	Cutis Laxa 11/2012
1	Alzheimer Disease (Alzheimer's Disease) 11/2009
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2008

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2023 - 05/2007
5	Retinaldehyde (Retinal)IBA 01/2024 - 11/2017
3	Glycoproteins (Glycoprotein)IBA 05/2024 - 12/2016
3	trabecular meshwork-induced glucocorticoid response proteinIBA 12/2022 - 04/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2024 - 06/2008
2	Amyloid (Amyloid Fibrils)IBA 01/2023 - 11/2014
2	Extracellular Matrix ProteinsIBA 01/2021 - 12/2011
2	Thymidine Monophosphate (TMP)IBA 01/2021 - 12/2019
2	Epidermal Growth Factor (EGF)IBA 01/2015 - 12/2011
2	fibulinIBA 11/2012 - 12/2011
2	alpha-SynucleinIBA 06/2008 - 12/2007
1	UbiquitinIBA 01/2024
1	Protein AggregatesIBA 01/2023
1	LipidsIBA 01/2023
1	Adenosine Monophosphate (AMP)IBA 12/2022
1	Trimethoprim (Proloprim)FDA LinkGeneric 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Nuclear RNAIBA 01/2020
1	SynucleinsIBA 01/2020
1	Cysteine Proteases (Cysteine Protease)IBA 08/2019
1	Matrix Metalloproteinases (MMPs)IBA 08/2019
1	Serine Proteases (Serine Protease)IBA 08/2019
1	Peptide Hydrolases (Proteases)FDA Link 08/2019
1	CollagenIBA 01/2018
1	LipofuscinIBA 11/2017
1	CytokinesIBA 01/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	DisulfidesIBA 12/2016
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	CalciumIBA 01/2015
1	Amyloidogenic ProteinsIBA 11/2014
1	Amyloid beta-PeptidesIBA 11/2009

Therapy/Procedure

3	Therapeutics 05/2022 - 01/2016
1	Rejuvenation 12/2023
1	Corneal Transplantation (Keratoplasty) 01/2020
1	Drug Therapy (Chemotherapy) 09/2014